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Publication (most recent)

  1. Asher, W.B., Terry, D.S., Gregorio, G.G.A., Kahsai, A.W., Borgia, A., Xie, B., Modak, A., Zhu, Y., Jang, W., Govindaraji, A., Huang, L., Inoue, A., Lambert, N.A., Gurevich, V.V., Shi, L., Lefkowitz, R.J., Blanchard, S.C., and Javich, J.A. GPCR-mediated β-arrestin Activation Deconvoluted with Single-molecule Precision. Cell. In Press April, 2022.

  2. Utz, P.J., Jain, M.K., Cheung, V.G., Kobilka, B.K., Lefkowitz, R.J., Yamada, T., and Dzau, V.J. Translating science to medicine: The case for physician-scientists. Sci. Transl. Med. 14(632), 2022.

  3. Zang, Y., Kahsai, A.W., Pakharukova, N., Huang, L., and Lefkowitz, R.J. GPCR-β-arrestin complexes allosterically activate C-Raf by binding its amino-terminus. J. Biol. Chem. 297(6):101369, 2021. PMCID: PMC8633562

  4. Wang, J., Pani, B., Gokhan, I., Xiong, X., Kahsai, A.W., Jiang, H., Ahn, S., Lefkowitz, R.J., and Rockman, H.A. β-arrestin-biased allosteric modulator potentiates Carvedilol stimulated β adrenergic receptor cardioprotection. Mol. Pharmacol. 100(6):568-579, 2021. PMCID: PMC8626783

  5. Pani, B., Ahn, S., Rambarat, P.K., Vege, S., Kahsai, A.W., Liu, A., Staus, D.P., Costa, T., and Lefkowitz, R.J. Unique positive cooperativity between the β-arrestin-biased β-blocker Carvedilol and a small molecule positive allosteric modulator of the β2-Adrenergic Receptor. Molecular Pharmacology. September 27, 2021. MOLPHARM-AR-2021-000363; DOI: In press.

  6. Nguyen, A.H. and Lefkowitz, R.J. Signaling at the endosome: cryo-EM structure of a GPCR–G protein–beta-arrestin megacomplex. The FEBS Journal. Feb, 2021. PMCID: PMC8252779

  7. Pakharukova, N., Masoudi, A., Pani, B., Staus, D.P., and Lefkowitz, R.J. Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes. Journal of Biological Chemistry. Dec 4, 2020, 295(49):16773-16784. PMCID: PMC7864071

  8. Wang, J., Gokhan, I., Xiong, X., Kahsai, A.W., Jiang, H., Pfeiffer, C.T., Tian, W., Pani, B., Ahn, S., and Lefkowitz, R.J. Abstract MP133: Development of β-arrestin-biased Positive Allosteric Modulators for the β1 Adrenergic Receptor. Circulation Research. Oct 27, 2020. 127: AMP133

  9. McMahon, C., Staus, D.P., Wingler, L.M., Wang, J., Skiba, M.A., Elgeti, M., Hubbell, W., Rockman, H.A., Kruse, A.C., and Lefkowitz, R.J. Synthetic nanobodies as angiotensin receptor blockers. PNAS. Aug 18, 2020,117(33):20284-20291. PMCID: PMC7443875

  10. Wingler, L.M. and Lefkowitz, R.J. Conformational basis of G protein-coupled receptor signaling versatility. Trends Cell Biol. Sep 2020, 30(9):736-747. PMCID: PMC7483927

  11. Ahn S, Shenoy SK, Luttrell LM, Lefkowitz RJ. SnapShot: β-Arrestin Functions. Cell. 2020 Sep 3;182(5):1362-1362.e1. doi: 10.1016/j.cell.2020.07.034. PM:32888497

  12. Manglik, A., Wingler, L.M., Rockman, H.A., and Lefkowitz, R.J. β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19. Circulation. Jul 28, 2020,142(4):318-320. PMCID: PMC7382535

  13. Kim, J., Grotegut, C.A., Wisler, J.W., Mao, L., Rosenberg, P.B., Rockman, H.A., and Lefkowitz, R.J. The β-arrestin biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility. PNAS. June 2, 117 (22): 12435-12443, 2020. PMCID: PMC6309084

  14. Staus, D.P., Hu, H., Robertson, M.J., Kleinhenz, A.L.W., Wingler, L.M., Capel, W.D., Latorraca, N.R., Lefkowitz, R.J, and Skiniotis, G. Structure of the M2 Muscarinic Receptor-β-arrestin Complex in a Lipid Nanodisc. Nature. Mar; 579(7798):297-302, 2020. PMCID: PMC7367492.

  15. Wingler, L.M., Skiba, M.A., McMahon, C., Staus, D.P., Kleinhenz, A.L.W., Suomivuori, C-M, Latorraca, N.R., Dror, R.O., Lefkowitz, R.J., and Kruse, A.C. Angiotensin and Biased Analogs Induce Structurally Distinct Active Conformations within a GPCR. Science. Feb 21; 367(6480):888-892, 2020. PMCID: PMC7171558.

  16. Suomivuori, C-M, Latorraca, N.R., Wingler, L.M., Eismann, S., King, M.C., Klenhenz, A.L.W., Skiba, M.A., Staus, D.P., Kruse, A.C., Lefkowitz, R.J., and Dror, R.O. Molecular Mechanism of Biased Signaling in a Prototypical G-Protein-Coupled Receptor. Science. Feb 21; 367(6480):881-887, 2020. PMCID: PMC7259329.

  17. Jain, M.K., Yamada, T., Lefkowitz, R.J. We Need More Doctors Who Are Scientists. New York Times. Sept. 23, 2019.

  18. Nguyen, A.H., Thomsen, A.R.B., Cahill III, T.J., Huang, R., Huang, L., Marcink, T., Clarke, O.B., Hissel, S., Masoudi, A., Ben-Hail, D., Samaan, F., Dandey, V.P., Tan, Y.Z., Hong, C., Mahoney, J.P., Triest, S., Little IV, J., Chen, X., Sunahara, R., Steyaert, J., Molina, H., Yu, Z., des Georges, A., Lefkowitz, R.J. Structure of an Endosomal Signaling GPCR-G Protein-β-arrestin Mega-Complex. Nature Structural and Molecular Biology. Dec; 26(12):1123-1131, 2019. PMCID: PMC7108872.

  19. Jain, M.K., Cheung, V.G., Utz, P.J., Kobilka, B.K., Yamada, T., Lefkowitz, R.J. Saving the Endangered Physican-Scientist – A Plan for Accelerating Medical Breakthroughs. N Engl J Med. August 1; 381:399-402, 2019.

  20. Staus, D.P., Wingler, L.M., Pichugin, D., Prosser, R.S., Lefkowitz, R.J. Detergent- and Phospholipid-Based Reconstruction Systems Have Differential Effects on Constitutive Activity of G-Protein-Coupled Receptors. J. Biol, Chem. July 30; 294(36):13218-13223, 2019. PMCID: PMC6737212.

  21. Liu, X., Masoudi, A., Kahsai, A.W., Huang, L.Y., Pani, B., Staus, D.P., Shim, P.J., Hirata, K., Simhal, R.K., Schwalb, A.M., Rambarat, P.K., Ahn, S., Lefkowitz, R.J., Kobilka, B. Mechanism of β2AR Regulation by an Intracellular Positive Allosteric Modulator. Science. June 28; 364(6447): 1283-1287, 2019. PMCID: PMC6705129.

  22. Wingler, L.M., McMahon, C., Staus, D.P., Lefkowitz, R.J., Kruse, A.C. Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell. Jan. 24; 176(3): 479-490, 2019. PMCID: PMC6367718.

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