Publication (most recent)
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Asher, W.B., Terry, D.S., Gregorio, G.G.A., Kahsai, A.W., Borgia, A., Xie, B., Modak, A., Zhu, Y., Jang, W., Govindaraji, A., Huang, L., Inoue, A., Lambert, N.A., Gurevich, V.V., Shi, L., Lefkowitz, R.J., Blanchard, S.C., and Javich, J.A. GPCR-mediated β-arrestin Activation Deconvoluted with Single-molecule Precision. Cell. In Press April, 2022.
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Utz, P.J., Jain, M.K., Cheung, V.G., Kobilka, B.K., Lefkowitz, R.J., Yamada, T., and Dzau, V.J. Translating science to medicine: The case for physician-scientists. Sci. Transl. Med. 14(632), 2022.
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Zang, Y., Kahsai, A.W., Pakharukova, N., Huang, L., and Lefkowitz, R.J. GPCR-β-arrestin complexes allosterically activate C-Raf by binding its amino-terminus. J. Biol. Chem. 297(6):101369, 2021. PMCID: PMC8633562
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Wang, J., Pani, B., Gokhan, I., Xiong, X., Kahsai, A.W., Jiang, H., Ahn, S., Lefkowitz, R.J., and Rockman, H.A. β-arrestin-biased allosteric modulator potentiates Carvedilol stimulated β adrenergic receptor cardioprotection. Mol. Pharmacol. 100(6):568-579, 2021. PMCID: PMC8626783
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Pani, B., Ahn, S., Rambarat, P.K., Vege, S., Kahsai, A.W., Liu, A., Staus, D.P., Costa, T., and Lefkowitz, R.J. Unique positive cooperativity between the β-arrestin-biased β-blocker Carvedilol and a small molecule positive allosteric modulator of the β2-Adrenergic Receptor. Molecular Pharmacology. September 27, 2021. MOLPHARM-AR-2021-000363; DOI: https://doi.org/10.1124/molpharm.121.000363. In press.
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Nguyen, A.H. and Lefkowitz, R.J. Signaling at the endosome: cryo-EM structure of a GPCR–G protein–beta-arrestin megacomplex. The FEBS Journal. Feb, 2021. PMCID: PMC8252779
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Pakharukova, N., Masoudi, A., Pani, B., Staus, D.P., and Lefkowitz, R.J. Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes. Journal of Biological Chemistry. Dec 4, 2020, 295(49):16773-16784. PMCID: PMC7864071
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Wang, J., Gokhan, I., Xiong, X., Kahsai, A.W., Jiang, H., Pfeiffer, C.T., Tian, W., Pani, B., Ahn, S., and Lefkowitz, R.J. Abstract MP133: Development of β-arrestin-biased Positive Allosteric Modulators for the β1 Adrenergic Receptor. Circulation Research. Oct 27, 2020. 127: AMP133
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McMahon, C., Staus, D.P., Wingler, L.M., Wang, J., Skiba, M.A., Elgeti, M., Hubbell, W., Rockman, H.A., Kruse, A.C., and Lefkowitz, R.J. Synthetic nanobodies as angiotensin receptor blockers. PNAS. Aug 18, 2020,117(33):20284-20291. PMCID: PMC7443875
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Wingler, L.M. and Lefkowitz, R.J. Conformational basis of G protein-coupled receptor signaling versatility. Trends Cell Biol. Sep 2020, 30(9):736-747. PMCID: PMC7483927
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Ahn S, Shenoy SK, Luttrell LM, Lefkowitz RJ. SnapShot: β-Arrestin Functions. Cell. 2020 Sep 3;182(5):1362-1362.e1. doi: 10.1016/j.cell.2020.07.034. PM:32888497
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Manglik, A., Wingler, L.M., Rockman, H.A., and Lefkowitz, R.J. β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19. Circulation. Jul 28, 2020,142(4):318-320. PMCID: PMC7382535
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Kim, J., Grotegut, C.A., Wisler, J.W., Mao, L., Rosenberg, P.B., Rockman, H.A., and Lefkowitz, R.J. The β-arrestin biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility. PNAS. June 2, 117 (22): 12435-12443, 2020. PMCID: PMC6309084
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Staus, D.P., Hu, H., Robertson, M.J., Kleinhenz, A.L.W., Wingler, L.M., Capel, W.D., Latorraca, N.R., Lefkowitz, R.J, and Skiniotis, G. Structure of the M2 Muscarinic Receptor-β-arrestin Complex in a Lipid Nanodisc. Nature. Mar; 579(7798):297-302, 2020. PMCID: PMC7367492.
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Wingler, L.M., Skiba, M.A., McMahon, C., Staus, D.P., Kleinhenz, A.L.W., Suomivuori, C-M, Latorraca, N.R., Dror, R.O., Lefkowitz, R.J., and Kruse, A.C. Angiotensin and Biased Analogs Induce Structurally Distinct Active Conformations within a GPCR. Science. Feb 21; 367(6480):888-892, 2020. PMCID: PMC7171558.
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Suomivuori, C-M, Latorraca, N.R., Wingler, L.M., Eismann, S., King, M.C., Klenhenz, A.L.W., Skiba, M.A., Staus, D.P., Kruse, A.C., Lefkowitz, R.J., and Dror, R.O. Molecular Mechanism of Biased Signaling in a Prototypical G-Protein-Coupled Receptor. Science. Feb 21; 367(6480):881-887, 2020. PMCID: PMC7259329.
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Jain, M.K., Yamada, T., Lefkowitz, R.J. We Need More Doctors Who Are Scientists. New York Times. Sept. 23, 2019.
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Nguyen, A.H., Thomsen, A.R.B., Cahill III, T.J., Huang, R., Huang, L., Marcink, T., Clarke, O.B., Hissel, S., Masoudi, A., Ben-Hail, D., Samaan, F., Dandey, V.P., Tan, Y.Z., Hong, C., Mahoney, J.P., Triest, S., Little IV, J., Chen, X., Sunahara, R., Steyaert, J., Molina, H., Yu, Z., des Georges, A., Lefkowitz, R.J. Structure of an Endosomal Signaling GPCR-G Protein-β-arrestin Mega-Complex. Nature Structural and Molecular Biology. Dec; 26(12):1123-1131, 2019. PMCID: PMC7108872.
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Jain, M.K., Cheung, V.G., Utz, P.J., Kobilka, B.K., Yamada, T., Lefkowitz, R.J. Saving the Endangered Physican-Scientist – A Plan for Accelerating Medical Breakthroughs. N Engl J Med. August 1; 381:399-402, 2019.
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Staus, D.P., Wingler, L.M., Pichugin, D., Prosser, R.S., Lefkowitz, R.J. Detergent- and Phospholipid-Based Reconstruction Systems Have Differential Effects on Constitutive Activity of G-Protein-Coupled Receptors. J. Biol, Chem. July 30; 294(36):13218-13223, 2019. PMCID: PMC6737212.
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Liu, X., Masoudi, A., Kahsai, A.W., Huang, L.Y., Pani, B., Staus, D.P., Shim, P.J., Hirata, K., Simhal, R.K., Schwalb, A.M., Rambarat, P.K., Ahn, S., Lefkowitz, R.J., Kobilka, B. Mechanism of β2AR Regulation by an Intracellular Positive Allosteric Modulator. Science. June 28; 364(6447): 1283-1287, 2019. PMCID: PMC6705129.
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Wingler, L.M., McMahon, C., Staus, D.P., Lefkowitz, R.J., Kruse, A.C. Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell. Jan. 24; 176(3): 479-490, 2019. PMCID: PMC6367718.